ABSTRACT
Acute onset of chronic inflammatory demyelinating polyneuropathy (A-CIDP) presents significant difficulties in differential diagnosis with acute inflammatory demyelinating polyneuropathy (AIDP). The article presents review of literature about differential diagnosis between A-CIDP and AIDP and a clinical case of A-CIDP at 26-year-old man. The disease started after vaccination against influenza and an episode of enteritis, the clinical picture matched Guillain-Barré syndrome criteria, according to electromyography data: demyelinating lesion of the left facial nerve, motor and sensory fibers of the median and ulnar nerves on both sides, demyelinating lesions of motor fibers of the tibial nerve and peroneal nerve on both sides. Chronic inflammatory demyelinating polyneuropathy was diagnosed. Lack of effect from plasma exchange was the reason for changing the treatment to pulse therapy with prednisolone (with a subsequent transition to a 1 mg/kg dose and further reduction until canceled within 16 weeks). Response to prednisolone - rapid recovery of motor functions, which worsened significantly due to a new coronavirus infection during treatment in the neurology department. Further continuation of prednisolone therapy made it possible to restore motor functions completely, except mild prosopoparesis. At the same time, deep reflexes were absent;no significant EMG dynamics was observed. Considering the effect of glucocorticosteroids and lack of positive dynamics on the second electromyography, the patient was diagnosed as A-CIDP. © 2021 Volgograd State University. All rights reserved.